Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.1K citations · Full text

Dna, Engineering, Dna Analysis +20

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

A Ullrich, Lisa M. Coussens, Joel S. Hayflick et al. · Nature · 1984 · 2.8K citations

Tumor Biology, Carcinoma Cells, Medicine +9

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

A Ullrich, Jeffrey R. Bell, E. Y. Chen et al. · Nature · 1985 · 2.3K citations

Insulin Resistance, Metabolic Syndrome, Insulin Signaling +12

Coated pits, coated vesicles, and receptor-mediated endocytosis

Joseph L. Goldstein, Richard G.W. Anderson, Michael S. Brown · Nature · 1979 · 2.1K citations

Endocytic Pathway, Receptor-mediated Endocytosis, Endocytosis +3

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

Joseph L. Goldstein, Sandip K. Basu, Michael S. Brown · Methods in enzymology on CD-ROM/Methods in enzymology · 1983 · 1.6K citations

Low-density Lipoprotein, Endocytic Pathway, Lipoprotein Metabolism +4