Concepedia

Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development

Laura Mangiavini, Christophe Merceron, Elisa Araldi, Richa Khatri, Rita Gerard-O’Riley, Tremika LeShan Wilson, Erinn B. Rankin, Amato J. Giaccia, Ernestina Schipani

Developmental Biology · 2014 · 31 citations · 45 references

DOIFull text

Open access

Concepts

References

45

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text

, , +21

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

, , +9

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

A global double‐fluorescent Cre reporter mouse

Mandar D. Muzumdar, Bosiljka Tasic, Kazunari Miyamichi et al. · genesis · 2007 · 3.6K citations · Full text