Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis

<i>DPC4</i> , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

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Mechanism of activation of the TGF-β receptor

Jeffrey L. Wrana, Liliana Attisano, Rotraud Wieser et al. · Nature · 1994 · 2.3K citations

Signal Transduction, Molecular Physiology, Tgf-β Receptor +6

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

Sylviane Dennler · The EMBO Journal · 1998 · 1.8K citations · Full text

Signal Transduction, Molecular Physiology, Signaling Pathway +7

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

Leigh Zawel, Jia Le Dai, Phillip Buckhaults et al. · Molecular Cell · 1998 · 932 citations · Full text

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

Giorgio Lagna, Akiko Hata, Ali Hemmati‐Brivanlou et al. · Nature · 1996 · 911 citations

Molecular Physiology, Signal Transduction, Signaling Pathway +8