Vascular Endothelial Growth Factor +936 C/T Gene Polymorphism and Glioma Risk in a Chinese Han Population

Abstract

BACKGROUND: Angiogenesis plays an important role in tumor progression. The vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis. AIM: The objective of this study was to investigate the association between VEGF +936 C/T gene polymorphism and glioma risk in a Chinese Han population. METHODS: We extracted the peripheral blood samples in 160 glioma patients and 320 controls. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: Glioma patients had a significantly higher frequency of TT genotype (odds ratio [OR] = 3.75, 95% confidence interval [CI] = 1.24, 11.40; p = 0.02) than controls. Glioblastoma patients had a significantly higher frequency of TT genotype (OR = 3.05, 95% CI = 1.11, 8.37; p = 0.03) than other gliomas. Patients with grade IV glioma had a significantly higher frequency of TT genotype (OR = 3.12, 95% CI = 1.14, 8.58; p = 0.03) than low-grade glioma. CONCLUSION: Our study indicated that VEGF + 936 C/T genotype was associated with a higher glioma risk in a Chinese Han population.