Tumors of the Brain and Nervous System after Radiotherapy in Childhood

TLDR

We investigated the relation between childhood radiotherapy for tinea capitis and later development of brain and nervous system tumors among 10,834 patients treated 1948‑1960 in Israel. Benign and malignant tumors were identified from pathology records and national registries, and radiation doses to neural tissue were retrospectively estimated (mean 1.5 Gy). Sixty neural tumors developed, giving a 30‑year cumulative risk of 0.8 % and an incidence of 1.8 per 10,000 person‑years; relative risk versus matched controls was 6.9 overall (8.4 for head‑neck neural tumors), with a dose‑response up to a relative risk of ~20 at ~2.5 Gy, confirming that 1–2 Gy doses markedly increase neural tumor risk.

Abstract

We investigated the relation between radiotherapy in childhood for tinea capitis and the later development of tumors of the brain and nervous system among 10,834 patients treated between 1948 and 1960 in Israel. Benign and malignant tumors were identified from the pathology records of all Israeli hospitals and from Israeli national cancer and death registries. Doses of radiation to the neural tissue were retrospectively estimated for each patient (mean, 1.5 Gy). Sixty neural tumors developed in the patients exposed as children, and the 30-year cumulative risk (+/- SE) was 0.8 +/- 0.2 percent. The incidence of tumors was 1.8 per 10,000 persons per year. The estimated relative risk as compared with that for 10,834 matched general-population controls and 5392 siblings who had not been irradiated was 6.9 (95 percent confidence interval, 4.1 to 11.6) for all tumors and 8.4 (confidence interval, 4.8 to 14.8) when the analysis was restricted to neural tumors of the head and neck. Increased risks were apparent for meningiomas (relative risk, 9.5; n = 19), gliomas (relative risk, 2.6; n = 7), nerve-sheath tumors (relative risk, 18.8; n = 25), and other neural tumors (relative risk, 3.4; n = 9). A strong dose--response relation was found, with the relative risk approaching 20 after estimated doses of approximately 2.5 Gy. Our study confirms that radiation doses on the order of 1 to 2 Gy can significantly increase the risk of neural tumors.