Mutations of mitotic checkpoint genes in human cancers

Daniel P. Cahill, Christoph Lengauer, Jian Yu, +5

Nature

Somatic VariantCancer GenomicsCancer GeneticsMedicineCell Biology +3

Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse

Josiane Ménissier de Murcia

The EMBO Journal

Knockout MouseChromatinDevelopmental BiologyChromosome StabilityCell Division +11

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B

Sandra Hanks, Kim Coleman, Sarah Reid, +13

Nature Genetics

Biallelic MutationsSomatic VariantGenetic DisorderGeneticsPathology +5

Control of the SCFSkp2–Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase

Tarig Bashir, N. Valerio Dorrello, Virginia Amador, +2

Nature

Protein FunctionSignal TransductionCell RegulationMolecular RegulationNatural Sciences +9

Polo-like kinase-1 is a target of the DNA damage checkpoint

Veronique A. J. Smits, Rob Klompmaker, Lionel Arnaud, +3

Nature Cell Biology

ChromatinGenome InstabilityCell RegulationMedicineNatural Sciences +7

Proteasome-Mediated Degradation of p21 via N-Terminal Ubiquitinylation

Joanna Bloom, Virginia Amador, Francesca Bartolini, +2

Cell

Protein FunctionBiochemistryNatural SciencesProteasomeProteasome-mediated Degradation +2

Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with <b> <i>BubR1</i> </b> Haploinsufficiency

Wei Dai, Qi Wang, Tongyi Liu, +7

Cancer Research

DNA Damage during Mitosis in Human Cells Delays the Metaphase/Anaphase Transition via the Spindle-Assembly Checkpoint

Alexei Mikhailov, Richard W. Cole, Conly L. Rieder

Current Biology

ChromatinGenome InstabilityDna DamageCell DivisionMedicine +9

Poly(ADP-ribose) is required for spindle assembly and structure

Paul Chang, Myron K. Jacobson, Timothy J. Mitchison

Nature

Materials SciencePolymer MaterialEngineeringSelf-assemblyPolymer Science +4

Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis

Juan A. Bernal, Rosa Luna, Águeda G. Espina, +7

Nature Genetics

Signal TransductionApoptosisMolecular BiologyCell DeathP53-mediated Transcriptional Activity +4