Increase Caused by Interleukin-6 in Promoter Activity of Guinea Pig Liver Transglutaminase Gene

Koji Ikura, Rika Shinagawa, Naoki Suto, Ryuzo Sasaki

Bioscience Biotechnology and Biochemistry · 1994 · 19 citations · 1 references

Concepts

Abstract

A 5'-flanking region (-2024 to +61) of the guinea pig liver transglutaminase gene and some 5'-deletion mutants were tested for promoter activity in human hepatoblastoma HepG2 cells treated with interleukin-6 (IL-6) by an assay of the transient expression of the chloramphenicol acetyltransferase reporter gene. The promoter activity of the 5'-flanking region introduced into the HepG2 cells was increased by IL-6.

References

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