Novel protease inhibitor-loaded Nanoparticle-in-Microparticle Delivery System leads to a dramatic improvement of the oral pharmacokinetics in dogs

Antiretroviral Treatment of Adult HIV Infection

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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

Oral Bioavailability, Immunology, Pharmacotherapy +17

Investigation of swelling/degradation behaviour of alginate beads crosslinked with Ca2+ and Ba2+ ions

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HIV-1 Protease Inhibitors Are Substrates for the<i>MDR</i>1 Multidrug Transporter

Caroline Lee, Michael M. Gottesman, Carol Cardarelli et al. · Biochemistry · 1998 · 481 citations

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Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate–chitosan beads

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Calcium Alginate, Vitro Release, Biomedical Engineering +1