FEBS Letters · 2010 · 25 citations · 31 references
Life SciencesCell BiologyImmunologyCell SignalingMolecular Cell BiologySignal TransductionImmune Cell SignalingLipid SignalingReceptor Tyrosine Kinase SignalingT Cell Activation ControlT Cell BiologyT Cell Receptor SignalingErk SignalingPhosphatidylinositol 3, 4, 5-Trisphosphate SignalingPhosphatidylinositol 4, 5-BisphosphatePhosphoinositide 3-Kinase-akt SignalingPi3k-akt Signaling PathwayT Cell Activation CytokinesT Cell Cytokine SignalingTyrosine Phosphorylation Signaling
Phosphatidylinositol 5-phosphate (PtdIns5P) is emerging as a potential lipid messenger involved in several cell types, from plants to mammals. Expression of IpgD, a PtdIns(4,5)P(2) 4-phosphatase induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a new PtdIns5P interacting domain blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering. Altogether, these data suggest that PtdIns5P may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis.
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A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
Lucia E. Rameh, Kimberley F. Tolias, Brian Duckworth et al. · Nature · 1997 · 456 citations