Concepedia

The mammalian metabolite, 2-methoxyestradiol, affects p53 levels and apoptosis induction in transformed cells but not in normal cells

J.C. Seegers, Mona‐Liza Lottering, Christina J.S. Grobler, D.H. van Papendorp, Robert C. Habbersett, Yulin Shou, Bruce E. Lehnert

The Journal of Steroid Biochemistry and Molecular Biology · 1997 · 99 citations · 37 references

DOI

Concepts

References

37

Participation of p53 protein in the cellular response to DNA damage.

Michael B. Kastan, Onyinye Onyekwere, D Sidransky et al. · PubMed · 1991 · 3.8K citations

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Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Steven J. Kuerbitz, Beverly Plunkett, William Walsh et al. · Proceedings of the National Academy of Sciences · 1992 · 1.9K citations

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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

Vjekoslav Dulić, William K. Kaufmann, S J Wilson et al. · Cell · 1994 · 1.5K citations

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p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

Manu Agarwal, Ashok Agarwal, William R. Taylor et al. · Proceedings of the National Academy of Sciences · 1995 · 863 citations

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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

William G. Nelson, Michael B. Kastan · Molecular and Cellular Biology · 1994 · 838 citations · Full text

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