A novel bombesin receptor antagonist inhibits autocrine signals in a small cell lung carcinoma cell line

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

Peter J. Munson, David Rodbard · Analytical Biochemistry · 1980 · 8.5K citations

Life Sciences, Chemistry, Biomolecular Modeling +11

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

Michael J. Berridge, C. Peter Downes, Michael R. Hanley · Biochemical Journal · 1982 · 2.1K citations · Full text

Medicine, Biochemistry, Pharmacology +12

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

Frank Cuttitta, Desmond N. Carney, James L. Mulshine et al. · Nature · 1985 · 1.4K citations

Medicine, Cancer Biology, Oncology +11

Establishment and identification of small cell lung cancer cell lines having classic and variant features

Desmond N. Carney, Adi F. Gazdar, Gerold Bepler et al. · Lung Cancer · 1986 · 912 citations

Medicine, Cell Biology, Oncology +12