Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

H. R. Michie, Kirk R. Manogue, David R. Spriggs et al. · New England Journal of Medicine · 1988 · 1.7K citations

Veterinary Medicine, Immunology, Immunophysiology +11

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

Bruce Beutler, Nadia Krochin, Ian W. Milsark et al. · Science · 1986 · 1.3K citations

Life Sciences, Immunology, Molecular Biology +14

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

Seijiro Okusawa, Jeffrey A. Gelfand, Takashi Ikejima et al. · Journal of Clinical Investigation · 1988 · 988 citations · Full text

Medicine, Immunology, Pharmacology +17

Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.

Bruce Beutler, James A. Mahoney, Nguyen Le Trang et al. · The Journal of Experimental Medicine · 1985 · 826 citations · Full text

Life Sciences, Biochemistry, Immunology +16

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

A. Fontana, F. Kristensen, Robert Dubs et al. · The Journal of Immunology · 1982 · 752 citations · Full text

Life Sciences, Immunology, Neuroscience +17