Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic, Akira Suzuki, José Luís de la Pompa et al. · Cell · 1998 · 2.6K citations · Full text

Life Sciences, Cell Biology, Oncology +16

Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain

Fiona Doetsch, José Manuel García‐Verdugo, Arturo Álvarez-Buylla · Journal of Neuroscience · 1997 · 1.9K citations · Full text

Life Sciences, Developmental Biology, Neuroscience +17

Pten is essential for embryonic development and tumour suppression

Antonio Di Cristofano, Bárbara Pesce, Carlos Cordon‐Cardo et al. · Nature Genetics · 1998 · 1.5K citations

Life Sciences, Developmental Biology, Molecular Genetics +14

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

Merja Lakso, José G. Pichel, James Gorman et al. · Proceedings of the National Academy of Sciences · 1996 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Genetics +15

Mutation of <i>Pten/Mmac1</i> in mice causes neoplasia in multiple organ systems

Katrina Podsypanina, Lora H. Ellenson, Adriana Nemes et al. · Proceedings of the National Academy of Sciences · 1999 · 949 citations · Full text

Veterinary Medicine, Oncology, Pathology +17