Desymmetrization of <i>meso</i>‐2‐Alkene‐1,4‐diol Derivatives through Copper(I)‐Catalyzed Asymmetric Boryl Substitution and Stereoselective Allylation of Aldehydes

Abstract

Breaking the mirror: The reaction sequence described in the title was applied to the synthesis of a valuable chiral drug precursor and the rapid stereoselective assembly of complex compounds with multiple chiral centers (see scheme).