The mode of action of aspirin-like drugs

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Mats Hámberg, Jan Olof Svensson, B Samuelsson · Proceedings of the National Academy of Sciences · 1975 · 3.1K citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +14

Acetylation of prostaglandin synthase by aspirin.

G J Roth, N Stanford, Philip W. Majerus · Proceedings of the National Academy of Sciences · 1975 · 1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.

S L Hong, Lawrence Levine · Proceedings of the National Academy of Sciences · 1976 · 571 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17