Cycloartane-type triterpenes from Euphorbia fischeriana stimulate human CYP3A4 promoter activity

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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Medicine, Pharmacology, Toxicology +17

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of<i>CYP3A4</i>by Rifampicin through a Distal Enhancer Module

Bryan Goodwin, Ecushla Hodgson, Christopher Liddle · Molecular Pharmacology · 1999 · 643 citations

Medicine, Molecular Biology, Pharmacology +17

Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes

Odette A. Fahmi, Mary Kish, Sherri Boldt et al. · Drug Metabolism and Disposition · 2010 · 135 citations

Medicine, Pharmacology, Clinical Pharmacology +13

17-Hydroxy-jolkinolide B Inhibits Signal Transducers and Activators of Transcription 3 Signaling by Covalently Cross-Linking Janus Kinases and Induces Apoptosis of Human Cancer Cells

Ying Wang, Xiuquan Ma, Shou‐Sheng Yan et al. · Cancer Research · 2009 · 94 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +12

Cytotoxic Activity of Lupane-Type Triterpenes from<i>Glochidion sphaerogynum</i>and<i>Glochidion eriocarpum</i>Two of which Induce Apoptosis

Prapawadee Puapairoj, Waree Naengchomnong, Anake Kijjoa et al. · Planta Medica · 2005 · 73 citations

Life Sciences, Botany, Pharmacology +8