Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes

Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification

Jodi M. Maglich, Catherine M. Stoltz, Bryan Goodwin et al. · Molecular Pharmacology · 2002 · 652 citations

Medicine, Pharmacology, Toxicology +16

Co-Regulation of CYP3A4 and CYP3A5 and Contribution to Hepatic and Intestinal Midazolam Metabolism

Yvonne S. Lin, Amy L.S. Dowling, Sean Quigley et al. · Molecular Pharmacology · 2002 · 444 citations

Medicine, Molecular Biology, Pharmacology +17

The Conduct of In Vitro and In Vivo Drug‐Drug Interaction Studies: A PhRMA Perspective

Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf et al. · The Journal of Clinical Pharmacology · 2003 · 309 citations

Medicine, Pharmacokinetics, Pharmacology +17

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

Peter Tszki Wei, J Zhang, D. H. Dowhan et al. · The Pharmacogenomics Journal · 2002 · 238 citations

Life Sciences, Molecular Biology, Pharmacology +16

Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction

Odette A. Fahmi, Susan Hurst, David R. Plowchalk et al. · Drug Metabolism and Disposition · 2009 · 212 citations

Pharmacy, Pharmacokinetics, Pharmacology +17