Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Marcy E. MacDonald · Cell · 1993 · 8.4K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

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Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

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Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

Alexander Panov, Claire‐Anne Gutekunst, Blair R. Leavitt et al. · Nature Neuroscience · 2002 · 1K citations

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Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

Susan Browne, Allen C. Bowling, Usha MacGarvey et al. · Annals of Neurology · 1997 · 872 citations

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