Differential Regulation of Th1-Type and Th2-Type Cytokine Profiles in Pancreatic Islets of C57BL/6 and BALB/c Mice by Multiple Low Doses of Streptozotocin

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

David Fiorentino, M W Bond, Timothy R. Mosmann · The Journal of Experimental Medicine · 1989 · 2.7K citations

Life Sciences, Cell Biology, Immunology +17

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

Youhai Chen, Vijay K. Kuchroo, Jun-ichi Inobe et al. · Science · 1994 · 2K citations

Life Sciences, Immunology, Autoimmunity +16

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

A. A. Like, Aldo A. Rossini · Science · 1976 · 980 citations

Life Sciences, Immunology, Pathology +17

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

Nora Sarvetnick, Denny Liggitt, Sharon Pitts et al. · Cell · 1988 · 465 citations · Full text

Medicine, Endocrinology, Molecular Biology +14

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

Kenneth J. Pennline, Elizabeth Roque-Gaffney, Margaret Monahan · Clinical Immunology and Immunopathology · 1994 · 429 citations

Medicine, Endocrinology, Immunology +10