High-performance liquid chromatographic assay with UV detection for measurement of dihydrouracil/uracil ratio in plasma

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion.

Barry Harris, Seng-Jaw Soong, Robert B. Diasio · PubMed · 1990 · 445 citations

Medicine, Pharmacokinetics, Pharmacology +17

Population study of dihydropyrimidine dehydrogenase in cancer patients.

M C Etienne, J.-L. Lagrange, O. Dassonville et al. · Journal of Clinical Oncology · 1994 · 432 citations

Medicine, Oncology, Pharmacology +15

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy.

Zhihong Lu, Ruiwen Zhang, Robert B. Diasio · PubMed · 1993 · 374 citations

Medicine, Oncology, Pharmacology +14

Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene.

André B. P. Kuilenburg, Janet Haasjes, Dick J. Richel et al. · PubMed · 2000 · 360 citations

Life Sciences, Biochemistry, Pharmacology +14

Enzymes of uracil catabolism in normal and neoplastic human tissues.

Fardos N.M. Naguib, Mahmoud H. el Kouni · PubMed · 1985 · 278 citations

Life Sciences, Biochemistry, Pharmacology +14