Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

Ulf Gyllensten · Proceedings of the National Academy of Sciences · 1988 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines

Erik De Clercq, Takashi Sakuma, Masanori Baba et al. · Antiviral Research · 1987 · 513 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency

David A. Leib, Donald M. Coen, Connie L. Bogard et al. · Journal of Virology · 1989 · 370 citations · Full text

Life Sciences, Genetics, Molecular Biology +12

Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

Donald M. Coen, Magdalena Kosz‐Vnenchak, Jennie G. Jacobson et al. · Proceedings of the National Academy of Sciences · 1989 · 361 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

The Role of Herpes Simplex Virus Type 1 Thymidine Kinase in Pathogenesis

Stacey Efstathiou, Sharon D. Kemp, G. Darby et al. · Journal of General Virology · 1989 · 229 citations

Life Sciences, Genetics, Molecular Biology +14