Concepedia

Structure–activity relationship studies of SEN12333 analogues: Determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs

Corinne Beinat, Tristan A. Reekie, Samuel D. Banister, James O’Brien-Brown, Teresa Xie, Thao T. Olson, Yingxian Xiao, Andrew J. Harvey, Susan O’Connor, Carolyn Coles,

European Journal of Medicinal Chemistry · 2015 · 14 citations · 60 references

Open access

References

60

Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes

Richard A. Friesner, Robert B. Murphy, Matthew P. Repasky et al. · Journal of Medicinal Chemistry · 2006 · 6.9K citations

Pharmacy, Medicinal Chemistry, Computational Chemistry +16

Lead- and drug-like compounds: the rule-of-five revolution

Christopher A. Lipinski · Drug Discovery Today Technologies · 2004 · 6.1K citations

Pharmacy, Chemistry, Medicinal Chemistry +14

The Many Roles for Fluorine in Medicinal Chemistry

William K. Hagmann · Journal of Medicinal Chemistry · 2008 · 3.6K citations · Full text

Pharmacy, Medicinal Chemistry, Drug Design +5

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

Katjuša Brejc, Willem J. van Dijk, Remco V. Klaassen et al. · Nature · 2001 · 1.8K citations

Life Sciences, Biophysics, Molecular Biology +17

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

Philippe Séguéla, Jacques I. Wadiche, Kelly Dineley‐Miller et al. · Journal of Neuroscience · 1993 · 1.5K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17