Concepedia

Synthesis and biological evaluation of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Dae‐Kee Kim, Sun Hee Jung, Ho Soon Lee, Purushottam Dewang

European Journal of Medicinal Chemistry · 2008 · 25 citations · 21 references

DOI

Concepts

References

21

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

Gareth J. Inman, Francisco José Nicolás, James F. Callahan et al. · Molecular Pharmacology · 2002 · 1.7K citations

, , +13

TGFβ signals through a heteromeric protein kinase receptor complex

Jeffrey L. Wrana, Liliana Attisano, Juan M. Cárcamo et al. · Cell · 1992 · 1.5K citations

, , +14

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

Fang Liu, Célio Pouponnot, Joan Massagué · Genes & Development · 1997 · 440 citations · Full text

, , +16

SB-505124 Is a Selective Inhibitor of Transforming Growth Factor-β Type I Receptors ALK4, ALK5, and ALK7

Stacey DaCosta Byfield, Christopher Major, Nicholas J. Laping et al. · Molecular Pharmacology · 2004 · 416 citations

, , +13

SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma Cells<b><i>In vitro</i></b>and<b><i>In vivo</i></b>

Martin Uhl, Steffen Aulwurm, Jörg Wischhusen et al. · Cancer Research · 2004 · 412 citations · Full text

, , +17