Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

François Ghiringhelli, Lionel Apétoh, Antoine Tesnière, +23

Nature Medicine

InflammationCancer ImmunosurveillanceNlrp3 InflammasomeImmunologyTumor Immunity +11

Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA–09): a randomised, open-label, phase 3 trial

Ulrich Herrlinger, Theophilos Tzaridis, Frederic Mack, +45

The Lancet

Hematological MalignancyNeuro-oncologyTreatment StrategiesMedicineStandard Temozolomide Therapy +11

SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma Cells<b><i>In vitro</i></b>and<b><i>In vivo</i></b>

Martin Uhl, Steffen Aulwurm, Jörg Wischhusen, +12

Cancer Research

Bevacizumab Plus Irinotecan Versus Temozolomide in Newly Diagnosed O⁶-Methylguanine–DNA Methyltransferase Nonmethylated Glioblastoma: The Randomized GLARIUS Trial

Ulrich Herrlinger, Niklas Schäfer, Astrid Weyerbrock, +33

Journal of Clinical Oncology

Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells

Martin Uhl, Oliver Kepp, Hélène Jusforgues-Saklani, +3

Cell Death and Differentiation

Autoimmune DiseaseImmunologyAutophagyAntiviral ResponseVirology +7

NOA‐03 trial of high‐dose methotrexate in primary central nervous system lymphoma: Final report

Ulrich Herrlinger, Wilhelm Küker, Martin Uhl, +5

Annals of Neurology

Inhibiting TGF-β signaling restores immune surveillance in the SMA-560 glioma model

Thomas-Toan Tran, Martin Uhl, Ying Jing, +19

Neuro-Oncology

Restores Immune SurveillanceImmune RegulationImmunologyImmunoeditingHigh-grade Gliomas +20

Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas

Martin Uhl, Markus Weiler, Wolfgang Wick, +3

Biochemical and Biophysical Research Communications

Neuro-oncologyEmbryonic Stem CellCell TherapyGliomaMedicine +12

Antigen Persistence Is Required for Dendritic Cell Licensing and CD8+ T Cell Cross-Priming

Hélène Jusforgues-Saklani, Martin Uhl, Nathalie E. Blachère, +6

The Journal of Immunology

Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2

Corinna Seliger, Anne-Louise Meyer, Kathrin Renner, +15

Cell Cycle

Neuro-oncologyGliomaPrimary BticsMedicinePharmacology +13