Concepedia

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB

Jeremy P. Mallari, Anang A. Shelat, Aaron Kosinski, Conor R. Caffrey, Michele Connelly, Fangyi Zhu, James H. McKerrow, R. Kiplin Guy

Bioorganic & Medicinal Chemistry Letters · 2008 · 58 citations · 16 references

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16

2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents

Daniel L. Klayman, J. F. BARTOSEVICH, T. Scott Griffin et al. · Journal of Medicinal Chemistry · 1979 · 428 citations

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Synthesis and Structure−Activity Relationship Study of Potent Trypanocidal Thio Semicarbazone Inhibitors of the Trypanosomal Cysteine Protease Cruzain

Xiaohui Du, Chun Guo, Elizabeth Hansell et al. · Journal of Medicinal Chemistry · 2002 · 383 citations · Full text

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Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against <i>Plasmodium falciparum</i>, <i>Trypanosoma brucei</i>, and <i>Trypanosoma cruzi</i>

Doron C. Greenbaum, Zachary B. Mackey, Elizabeth Hansell et al. · Journal of Medicinal Chemistry · 2004 · 254 citations · Full text

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The phenomenon of treatment failures in Human African Trypanosomiasis

Reto Brun, Reto Schumacher, Cécile Schmid et al. · Tropical Medicine & International Health · 2001 · 186 citations

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Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense

Conor R. Caffrey, Elizabeth Hansell, Kimberley D. Lucas et al. · Molecular and Biochemical Parasitology · 2001 · 179 citations

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