Synthesis and Structure−Activity Relationship Study of Potent Trypanocidal Thio Semicarbazone Inhibitors of the Trypanosomal Cysteine Protease Cruzain

Xiaohui Du, Chun Guo, Elizabeth Hansell, +5

Journal of Medicinal Chemistry

Bioorganic ChemistryBiochemistryAntiparasitic AgentMedicineNatural Sciences +12

Lipopolysaccharide (LPS) promotes osteoclast differentiation and activation by enhancing the MAPK pathway and COX-2 expression in RAW264.7 cells

Guoqing Hou, Chun Guo, Guohua Song, +5

International Journal of Molecular Medicine

Lipopolysaccharide (LPS) Induces the Apoptosis and Inhibits Osteoblast Differentiation Through JNK Pathway in MC3T3-E1 Cells

Chun Guo, Lei Yuan, Jianguo Wang, +7

Inflammation

InflammationMc3t3-e1 CellsSclerostinBiochemistryBone Morphogenic Protein +13

Protective Effects of Pretreatment with Quercetin Against Lipopolysaccharide-Induced Apoptosis and the Inhibition of Osteoblast Differentiation via the MAPK and Wnt/β-Catenin Pathways in MC3T3-E1 Cells

Chun Guo, Ruijuan Yang, Ke Jang, +2

Cellular Physiology and Biochemistry

Design, synthesis, cytotoxicity and mechanism of novel dihydroartemisinin-coumarin hybrids as potential anti-cancer agents

Haonan Yu, Zhuang Hou, Ye Tian, +2

European Journal of Medicinal Chemistry

Medicinal ChemistryMedicineTumor TargetingNovel Dihydroartemisinin-coumarin HybridsPotential Anti-cancer Agents +5

Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents

Hang Xu, Xin Su, Mengbi Guo, +4

European Journal of Medicinal Chemistry

Medicinal ChemistryAntifungal AgentAntifungal AgentsMedicineNovel Miconazole Analogues +7

Design, Synthesis and Biological Evaluation of Novel 4-Substituted Coumarin Derivatives as Antitumor Agents

Ran An, Zhuang Hou, Jian-Teng Li, +3

Molecules

Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids

Zhen Liang, Hang Xu, Ye Tian, +3

Molecules

Medicinal ChemistryAntifungal AgentBioorganic ChemistryAntifungal AgentsDrug Discovery +11

Design, synthesis, and structure–activity relationships of novel 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents

Qidong Tang, Yanfang Zhao, Xinming Du, +3

European Journal of Medicinal Chemistry

Medicinal ChemistryMedicineDrug DiscoveryNovel 6,7-Disubstituted-4-phenoxyquinoline DerivativesAnti-cancer Agent +6

IL-1α induces apoptosis and inhibits the osteoblast differentiation of MC3T3-E1 cells through the JNK and p38 MAPK pathways

Chun Guo, Xuguang Yang, Fei Wang, +1

International Journal of Molecular Medicine

ApoptosisImmunologyImmune RegulationCell DeathInnate Immunity +19