Chemical genetics of Plasmodium falciparum

W. Armand Guiguemde, Anang A. Shelat, David C. Bouck, +31

Nature

BiologyBiochemical TaxonomyGeneticsMalariaMolecular Genetics +5

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of <i>Plasmodium</i>

Marı́a Belén Jiménez-Dı́az, Daniel Ebert, Yandira G. Salinas, +46

Proceedings of the National Academy of Sciences

Phenotypic ScreeningAntiparasitic AgentMalariaImmunologyMolecular Biology +15

Identification and Characterization of the First Small Molecule Inhibitor of MDMX

Damon R. Reed, Ying Shen, Anang A. Shelat, +12

Journal of Biological Chemistry

Small Molecule InhibitorsDrug TargetChemoprevention StrategyMolecular BiologyChemical Biology +17

Targeting the p53 Pathway in Retinoblastoma with Subconjunctival Nutlin-3a

Rachel C. Brennan, Sara M. Federico, Cori Bradley, +7

Cancer Research

Ocular DiseaseOncologyCell RegulationOphthalmologyMedicine +10

Lead Optimization of 3-Carboxyl-4(1<i>H</i>)-Quinolones to Deliver Orally Bioavailable Antimalarials

Yiqun Zhang, Julie Clark, Michele Connelly, +13

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceBioorganic ChemistryBiochemistryAntiparasitic Agent +11

Whole-Body Physiologically Based Pharmacokinetic Model for Nutlin-3a in Mice after Intravenous and Oral Administration

Fan Zhang, Michael Tagen, Stacy L. Throm, +13

Drug Metabolism and Disposition

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB

Jeremy P. Mallari, Anang A. Shelat, Aaron Kosinski, +5

Bioorganic & Medicinal Chemistry Letters

Trypanocidal Thiosemicarbazone InhibitorsAntiparasitic AgentMedicineAfrican TrypanosomiasisPharmacology +1

Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides

David Floyd, Philip D. Stein, Zheng Wang, +14

Journal of Medicinal Chemistry

Medicinal ChemistryPhenotypic Whole-cell ScreeningBiochemistryAntiparasitic AgentMedicine +13

Improvement of Pharmacological Properties of Irreversible Thyroid Receptor Coactivator Binding Inhibitors

Jong Yeon Hwang, Leggy A. Arnold, Fangyi Zhu, +5

Journal of Medicinal Chemistry

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening

Diana Ortiz, W. Armand Guiguemde, Jared T. Hammill, +13

PLoS neglected tropical diseases

Antiparasitic AgentMalariaAntileishmanial CompoundsMolecular BiologyChemical Biology +17