Increased efficacy of antileishmanial antisense phosphorothioate oligonucleotides in Leishmania amazonensis overexpressing ribonuclease H11Abbreviations: RNase H, ribonuclease H; S-oligo, phosphorothioate-modified oligodeoxyribonucleotide; LUAS, anti-luciferase antisense S-oligo; LUS, S-oligo complementary to LUAS; ASM, S-oligo antisense to Leishmania miniexon; SSM, S-oligo complementary to ASM; HIFBS, heat-inactivated fetal bovine serum; TbRH1, Trypanosoma brucei RNase H1 gene; RACE, rapid amplification of cDNA ends; MBSA, maleylated bovine serum albumin; ODN, oligodeoxyribonucleotide; PCR, polymerase chain reaction; and DMPC, dimyristoyl phosphatidylcholine.

Biochemical Pharmacology · 2001 · 15 citations · 43 references