Solution behavior of hematin under acidic conditions and implications for its interactions with chloroquine

Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

A.F.G. Slater, Anthony Cerami · Nature · 1992 · 651 citations

Life Sciences, Infectious Diseases, Molecular Biology +10

Four plasmepsins are active in the <i>Plasmodium falciparum</i> food vacuole, including a protease with an active-site histidine

Ritu Banerjee, Jun Liu, Wandy L. Beatty et al. · Proceedings of the National Academy of Sciences · 2002 · 457 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Malarial haemozoin/β-haematin supports haem polymerization in the absence of protein

Nature · 1995 · 389 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +2

An Assessment of Drug-Haematin Binding as a Mechanism for Inhibition of Haematin Polymerisation by Quinoline Antimalarials

Arnulf Dorn, Sudha Rani Vippagunta, Hugues Matile et al. · Biochemical Pharmacology · 1998 · 348 citations

Medicine, Medicinal Chemistry, Pharmacology +12

Structure−Function Relationships in Aminoquinolines:  Effect of Amino and Chloro Groups on Quinoline−Hematin Complex Formation, Inhibition of β-Hematin Formation, and Antiplasmodial Activity

Timothy J. Egan, Roger Hunter, Catherine H. Kaschula et al. · Journal of Medicinal Chemistry · 1999 · 311 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10