Concepedia

Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course

Ann M. Reed, Erik Peterson, Hatice Bilgiç, Steven R. Ytterberg, Shreyasee Amin, Molly S. Hein, Cynthia S. Crowson, Floranne C. Ernste, Emily Gillespie

Arthritis & Rheumatism · 2012 · 95 citations · 19 references

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Abstract

Our findings suggest that changes in type I IFN gene and chemokine scores as well as in levels of IL-6, IL-8, and TNFα may serve as sensitive and responsive longitudinal biomarkers of change in disease activity in juvenile and adult DM, even in the presence of immunomodulating agents.

References

19

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

Emily C. Baechler, Franak Batliwalla, George Karypis et al. · Proceedings of the National Academy of Sciences · 2003 · 2.2K citations · Full text

Type I interferon–inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis

Ronan J. Walsh, Sek Won Kong, Yihong Yao et al. · Arthritis & Rheumatism · 2007 · 300 citations · Full text

An Interferon Signature in the Peripheral Blood of Dermatomyositis Patients is Associated with Disease Activity

Emily C. Baechler, Jason W. Bauer, Catherine A. Slattery et al. · Molecular Medicine · 2007 · 300 citations · Full text

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Validation of manual muscle testing and a subset of eight muscles for adult and juvenile idiopathic inflammatory myopathies

Lisa G. Rider, Deloris E. Koziol, Edward H. Giannini et al. · Arthritis Care & Research · 2010 · 254 citations · Full text

Development of validated disease activity and damage indices for the juvenile idiopathic inflammatory myopathies: II. The childhood myositis assessment scale (CMAS): a quantitative tool for the evaluation of muscle function

Daniel J. Lovell, Carol B. Lindsley, Robert M. Rennebohm et al. · Arthritis & Rheumatism · 1999 · 238 citations