Concepedia

Therapeutic window of an EpCAM/CD3-specific BiTE antibody in mice is determined by a subpopulation of EpCAM-expressing lymphocytes that is absent in humans

Maria Amann, Matthias Friedrich, Petra Lutterbuese, Eva Vieser, Grit Lorenczewski, Laetitia Petersen, Klaus Brischwein, Peter Kufer, Roman Kischel, Patrick A. Baeuerle,

Cancer Immunology Immunotherapy · 2008 · 40 citations · 33 references

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33

Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers

Philip Went, Mohammad Vasei, Lukas Bubendorf et al. · British Journal of Cancer · 2006 · 384 citations · Full text

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A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity.

Matthias Mack, G. Riethmüller, Peter Kufer · Proceedings of the National Academy of Sciences · 1995 · 347 citations

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Expression of epithelial cell adhesion molecule in carcinoma cells present in blood and primary and metastatic tumors

David A. Chianese, Gerald V. Doyle, Michael Craig Miller et al. · International Journal of Oncology · 2005 · 328 citations

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MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors

Klaus Brischwein, Bernd Schlereth, Benjamin Guller et al. · Molecular Immunology · 2005 · 260 citations

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Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells.

Raphael Hirsch, Richard E. Gress, D H Pluznik et al. · The Journal of Immunology · 1989 · 198 citations · Full text

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