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Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases

Naoyuki Suzuki, Takeshi Shiota, Fumihiko Watanabe, Norihiro Haga, Takami Murashi, Takafumi Ohara, Kenji Matsuo, Naoki Omori, Hiroshi Yari, Keiji Dohi,

Bioorganic & Medicinal Chemistry Letters · 2011 · 17 citations · 11 references

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11

A small molecule–kinase interaction map for clinical kinase inhibitors

Miles A. Fabian, William Biggs, Daniel K. Treiber et al. · Nature Biotechnology · 2005 · 1.9K citations · Full text

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Prediction of Physicochemical Parameters by Atomic Contributions

Scott A. Wildman, Gordon M. Crippen · Journal of Chemical Information and Computer Sciences · 1999 · 1.5K citations

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A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib)

Edgar R. Wood, Anne T. Truesdale, Octerloney B. McDonald et al. · Cancer Research · 2004 · 1.1K citations · Full text

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BindingDB Entry 50022499: ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy.

PubMed · 2025 · 933 citations · Full text

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BindingDB Entry 50022536: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

PubMed · 2025 · 844 citations · Full text

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