Aldose reductase deficiency protects sugar-induced lens opacification in rats

Biochemistry and molecular cell biology of diabetic complications

Michael Brownlee · Nature · 2001 · 9K citations

Life Sciences, Biochemistry, Cell Biology +14

Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens.

Alan Yiu Wah Lee, Sookja Kim Chung, Stephen S.M. Chung · Proceedings of the National Academy of Sciences · 1995 · 310 citations

Life Sciences, Biochemistry, Genetics +15

Small interfering RNA and gene silencing in transgenic mice and rats

Hidetoshi Hasuwa, Kazuhiro Kaseda, Thorbjorg Einarsdottir et al. · FEBS Letters · 2002 · 266 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Metabolism of the Lipid Peroxidation Product, 4-Hydroxy-trans-2-nonenal, in Isolated Perfused Rat Heart

Sanjay Srivastava, Animesh Chandra, Lifei Wang et al. · Journal of Biological Chemistry · 1998 · 225 citations · Full text

Life Sciences, Biochemistry, Cellular Metabolism +10

Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of <i>db/db</i> Mice

Alvin K.H. Cheung, Maggie K.L. Fung, Terence T.L. Lam et al. · Diabetes · 2005 · 210 citations · Full text

Medicine, Endocrinology, Ophthalmology +17