Concepedia

Phase I Safety and Pharmacokinetic Study of the PI3K/mTOR Inhibitor SAR245409 (XL765) in Combination with Erlotinib in Patients with Advanced Solid Tumors

Pasi A. Jänne, Roger B. Cohen, Alexander Laird, Sandrine Macé, Jeffrey A. Engelman, Rodrigo Ruiz-Soto, Kevin Rockich, Jianbo Xu, Geoffrey I. Shapiro, Pablo Martínez,

Journal of Thoracic Oncology · 2014 · 49 citations · 14 references

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14

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Patrick Therasse, Susan G. Arbuck, Elizabeth A. Eisenhauer et al. · JNCI Journal of the National Cancer Institute · 2000 · 15.7K citations

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<i>MET</i> Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

Jeffrey A. Engelman, Kreshnik Zejnullahu, Tetsuya Mitsudomi et al. · Science · 2007 · 4.5K citations · Full text

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Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

Lecia V. Sequist, Belinda A. Waltman, Dora Dias‐Santagata et al. · Science Translational Medicine · 2011 · 3.6K citations · Full text

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag, Peter Hirth, James Tsai et al. · Nature · 2010 · 1.8K citations

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Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

J. A. Engelman, Toru Mukohara, Kreshnik Zejnullahu et al. · Journal of Clinical Investigation · 2006 · 457 citations · Full text

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