Autoimmunity and Inflammation Due to a Gain-of-Function Mutation in Phospholipase Cγ2 that Specifically Increases External Ca2+ Entry

RAG-1-deficient mice have no mature B and T lymphocytes

Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell · 1992 · 2.9K citations

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Hironori Ueda, Joanna M. M. Howson, Laura Esposito et al. · Nature · 2003 · 2.2K citations

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Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

Noriko Sakaguchi, Takeshi Takahashi, Hiroshi Hata et al. · Nature · 2003 · 875 citations

Life Sciences, Genetics, Immunology +14

Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion

Carle Ryckman, Karen Vandal, Pascal Rouleau et al. · The Journal of Immunology · 2003 · 857 citations · Full text

Life Sciences, Cell Biology, Immunology +14

B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

By Florienne Loder, Bettina Mutschler, Robert J. Ray et al. · The Journal of Experimental Medicine · 1999 · 843 citations · Full text

Life Sciences, Developmental Biology, Immunology +16