Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

Medicine, Cardiology, Molecular Genetics +16

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy

Early Breast Cancer Trialist's Collaborative Group · The Lancet · 1992 · 2.2K citations

Medicine, Immunology, Oncology +16

Ionic Blockage of Sodium Channels in Nerve

Ann M. Woodhull · The Journal of General Physiology · 1973 · 1.6K citations · Full text

Natural Sciences, Biophysics, Physiology +17

Fatal myocardial infarction in the Scottish adjuvant tamoxifen trial. The Scottish Breast Cancer Committee.

C. McDonald, Helen Stewart · BMJ · 1991 · 366 citations · Full text

Medicine, Cardiology, Oncology +11

Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment.

Ernst A. Lien, E. Solheim, Per Magne Ueland · PubMed · 1991 · 365 citations

Medicine, Pharmacokinetics, Pharmacology +16