Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

Masaaki Miyamoto, Takashi Fujita, Yoko Kimura et al. · Cell · 1988 · 1K citations

Life Sciences, Genetics, Molecular Biology +12

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

C A Chen, Hiroto Okayama · PubMed · 1990 · 898 citations

Life Sciences, Biotechnology, Molecular Biology +16

Transcriptional regulation

Nathaniel Helntz · Trends in Biochemical Sciences · 1991 · 892 citations

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

Klaus Giese, Jeffery S. Cox, Rudolf Grosschedl · Cell · 1992 · 681 citations

Life Sciences, Genetics, Molecular Biology +7

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

T. Matsuyama, Tohru Kimura, Motoo Kitagawa et al. · Cell · 1993 · 643 citations

Life Sciences, Genetics, Immunology +14