CrystEngComm · 2012 · 74 citations · 27 references
Natural SciencesChemistryMedicinal ChemistryDrug DesignOrganic ChemistryStructure-activity RelationshipsCarboxylic AcidsProtein StructureCrystal Structure DeterminationCrystal Structure RefinementMolecular Structure DeterminationPowder DiffractionPowder Diffraction AnalysisPowder X-ray DiffractionStructure-property Relationships In PolymorphsSupramolecular Synthons
Acemetacin is the first example of an API polymorph with a carboxylic acid catemer and dimer O–H⋯O synthons. The auxiliary stabilization to the catemer motif from stronger C–H⋯O and C–Cl⋯O interactions compared to those in the dimer structure is discussed for a polymorph pair. The crystal structure of the stable dimer polymorph was solved by structure determination from powder X-ray diffraction data (SDPD).
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