Synthetic Communications · 2003 · 90 citations · 23 references
Natural SciencesChemistryCatalysisNatural Product BiosynthesisOrganic ChemistryCatalyst PreparationCatalyst SynthesisHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisAmino Acid EstersKnoevenagel CondensationMild Reaction Conditions
Abstract A straightforward method for the synthesis of alkylidene/arylidene malonates and arylidene cyanoacetates, utilizing proline as an alternative to traditional catalysts is presented. A large number of unsaturated esters was obtained from the Knoevenagel reaction under very mild conditions and utilizing cheap reagents. Keywords: Knoevenagel condensationProlineAlkylidene malonateArylidene malonateArylidene cyanoacetate Acknowledgment We thank MURST (Cofin 2000, FIRB project, and 60%) and the University of Bologna (funds for selected topics) for financial support.
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Kandasamy Sakthivel, Wolfgang Notz, Tommy Bui et al. · Journal of the American Chemical Society · 2001 · 1.2K citations
Catalysis of organic reactions by inorganic solids
Pierre Laszlo · Accounts of Chemical Research · 1986 · 337 citations