Publication | Closed Access
A Straightforward Method for the Synthesis of Alkylidene and Arylidene Malonates Through Proline-Catalyzed Knoevenagel Condensation
90
Citations
23
References
2003
Year
EngineeringOrganic ChemistryArylidene CyanoacetatesChemistryFinancial SupportProline-catalyzed Knoevenagel CondensationCross-coupling ReactionDerivativesDiversity-oriented SynthesisCatalysisPharmacologyAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringAlkene MetathesisArylidene MalonatesNatural SciencesStraightforward MethodSynthetic Chemistry
Abstract A straightforward method for the synthesis of alkylidene/arylidene malonates and arylidene cyanoacetates, utilizing proline as an alternative to traditional catalysts is presented. A large number of unsaturated esters was obtained from the Knoevenagel reaction under very mild conditions and utilizing cheap reagents. Keywords: Knoevenagel condensationProlineAlkylidene malonateArylidene malonateArylidene cyanoacetate Acknowledgment We thank MURST (Cofin 2000, FIRB project, and 60%) and the University of Bologna (funds for selected topics) for financial support.
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