Multiplex Ligation-Dependent Probe Amplification of Conjunctival Melanoma Reveals Common<i>BRAF</i>V600E Gene Mutation and Gene Copy Number Changes

Abstract

No copy number changes were associated exclusively with metastatic CoMs. However, further investigation of the role of CDKN1A and RUNX2 in CoMs development and that of MLH1, TIMP2, MGMT, and ECHS1 in metastatic CoMs is warranted. Validation of the observed gene and chromosome arm copy number changes in a larger cohort of primary and metastatic CoMs is necessary to identify the patients at highest risk for CoMs metastasis.