European Journal of Organic Chemistry · 2001 · 13 citations · 0 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryMacrocycle SynthesisMacrocyclic Drug DesignRetrosynthetic AnalysisLactam MacrocyclesLactam SynthesisMacrocycle DiversificationSpirocyclic ScaffoldsSpiroheterocycle Synthesis
Spirocyclic amides are easily obtained from primary amines, cycloenones and acrylic acid methyl ester. The key step is a two-component domino process that includes the formation of an amide followed by a Michael addition in the presence of trimethylaluminum.