Concepedia

Mechanisms of Immune System Activation in Glaucoma: Oxidative Stress-Stimulated Antigen Presentation by the Retina and Optic Nerve Head Glia

Gu ̈lgu ̈n Tezel, Xiangjun Yang, Cheng Luo, Yong Peng, Sheher Sun, Deming Sun

Investigative Ophthalmology & Visual Science · 2007 · 159 citations · 56 references

DOIFull text

Open access

Abstract

These in vitro findings support that ROS regulate the immune response by stimulating the antigen-presenting ability of glial cells and functioning as costimulatory molecules for antigen presentation.

References

56

T‐lymphocyte entry into the central nervous system

William F. Hickey, Benjamin Hsu, Hironobu Kimura · Journal of Neuroscience Research · 1991 · 1.2K citations

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

Charles J. Lowenstein, Evan Alley, Pravin Raval et al. · Proceedings of the National Academy of Sciences · 1993 · 1.1K citations · Full text

, , +24

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

Klaus Schulze‐Osthoff, Annette Bakker, Bart Vanhaesebroeck et al. · Journal of Biological Chemistry · 1992 · 940 citations · Full text

Antigen presentation: comments on its regulation and mechanism.

Emil R. Unanue, D I Beller, Christina Lu et al. · The Journal of Immunology · 1984 · 499 citations · Full text

, , +3

Role of interferon regulatory factor 1 in induction of nitric oxide synthase.

Emil Martin, C F Nathan, Q W Xie · The Journal of Experimental Medicine · 1994 · 480 citations · Full text

, , +19