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Effect of Aflatoxin on Complement Activity in Guinea Pigs
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1972
Year
ImmunotoxicologyImmunologyComplement ActivityFood ToxicologyInflammationMycotoxin FormationToxicologyHepatotoxicitySummaryguinea PigsHealth SciencesAnimal PhysiologyLiver PhysiologyComplement TitersPharmacologyDrug-induced Liver InjuryComplement SystemHepatologyGuinea PigsMedicine
SummaryGuinea pigs were dosed once daily with partially purifed aflatoxin in measured amounts per os for 20 days. A significant average depression of complement titers occurred in guinea pigs given a daily dose of aflatoxin equivalent to 0.03 mg or greater of fraction B1. Guinea pigs given a daily dose of aflatoxin equivalent to 0.01 5 mg or greater of fraction B1 had average weight significantly below that of control guinea pigs. Microscopic changes in the liver were detected mostly in guinea pigs given 0.03 mg or more of B1 equivalents. Considerable individual variation in complement titers, weights, and liver changes were noted among the guinea pigs.