Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Mario F. Fraga, Esteban Ballestar, Ana Villar‐Garea et al. · Nature Genetics · 2005 · 1.9K citations

Histone Modifications, Tumor Biology, Chromatin +12

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

Alessandro Vannini, Cinzia Volpari, Gessica Filocamo et al. · Proceedings of the National Academy of Sciences · 2004 · 620 citations · Full text

Histone Modifications, Histone Deacetylases, Crystal Structure +17

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.

Lisa M. Butler, David B. Agus, Howard I. Scher et al. · PubMed · 2000 · 617 citations

Chemoprevention Strategy, Prostate Cancer Cells, Cancer Biology +18

Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer

Andrew J. Wilson, Do-Sun Byun, Lucas B. Murray et al. · Journal of Biological Chemistry · 2006 · 577 citations · Full text

Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis

Ping Zhu, Elke Martin, Jörg Mengwasser et al. · Cancer Cell · 2004 · 534 citations · Full text

Tumor Biology, Oncogenic Agent, Medicine +11