Elevated activated partial thromboplastin time during administration of first-generation adenoviral vectors for gene therapy for prostate cancer: Identification of lupus anticoagulants

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity

Gudrun Schiedner, Núria Morral, Robin J. Parks et al. · Nature Genetics · 1998 · 646 citations

Life Sciences, Biotechnology, Molecular Biology +16

The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors

André Lieber, C Y He, Leonard Meuse et al. · Journal of Virology · 1997 · 414 citations · Full text

Life Sciences, Immunology, Pathobiology +17

An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

Manal Morsy, Mingcheng Gu, Sherri L. Motzel et al. · Proceedings of the National Academy of Sciences · 1998 · 370 citations

Pharmacy, Molecular Biology, Molecular Genetics +16

Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Gene Therapy in Patients with Localized Malignancy: Results of a Phase I Clinical Trial in Malignant Mesothelioma

Daniel H. Sterman, Joseph Treat, Leslie A. Litzky et al. · Human Gene Therapy · 1998 · 345 citations

Medicine, Oncology, Pharmacology +15

In Situ Gene Therapy for Adenocarcinoma of the Prostate: A Phase I Clinical Trial

James R. Herman, Howard L. Adler, Estuardo Aguilar-Córdova et al. · Human Gene Therapy · 1999 · 306 citations

Medicine, Oncology, Pharmacology +16