Molecular therapy of obesity and diabetes by a physiological autoregulatory approach

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Vamsi K. Mootha, Cecilia M. Lindgren, Karl‐Fredrik Eriksson et al. · Nature Genetics · 2003 · 10.4K citations

Metabolic Syndrome, Human Diabetes, Biochemistry +10

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

Anders H. Berg, Terry P. Combs, Xueliang Du et al. · Nature Medicine · 2001 · 2.5K citations

Metabolic Syndrome, Hepatology, Biochemistry +9

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

Robert Frederich, A. Hamann, Stephen Anderson et al. · Nature Medicine · 1995 · 1.7K citations

Obesity, Metabolic Syndrome, Animal Physiology +12

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

Denis Arsenijevic, Hiroki Onuma, Claire Pecqueur et al. · Nature Genetics · 2000 · 1.1K citations

Inflammation, Uncoupling Protein-2 Gene, Reductive Stress +12

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

Baoji Xu, Evan H Goulding, Keling Zang et al. · Nature Neuroscience · 2003 · 872 citations · Full text

Energy Homeostasis, Molecular Physiology, Neurophysiology +10