An improved synthesis of 1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, a key intermediate for atorvastatin synthesis

Carbonate extension. A versatile procedure for functionalization of acyclic homoallylic alcohols with moderate stereocontrol

Paul A. Bartlett, James D. Meadows, Edward Brown et al. · The Journal of Organic Chemistry · 1982 · 130 citations

Natural Sciences, Chemistry, Analytical Chemistry +5

Iodine monobromide (IBr) at low temperature: enhanced diastereoselectivity in electrophilic cyclizations of homoallylic carbonates

James J.‐W. Duan, Amos B. Smith · The Journal of Organic Chemistry · 1993 · 127 citations

Natural Sciences, Chemistry, Inorganic Chemistry +5

The convergent synthesis of CI-981, an optically active, highly potent, tissue selective inhibitor of HMG-CoA reductase

Kelvin L. Baumann, Donald E. Butler, Carl F. Deering et al. · Tetrahedron Letters · 1992 · 123 citations

Pharmacy, Medicinal Chemistry, Pharmacology +7

Atorvastatin Calcium

A. Graul, J. Castañer · Drugs of the Future · 1997 · 100 citations

The synthesis of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, a key intermediate for the preparation of CI-981, a highly potent, tissue selective inhibitor of HMG-CoA reductase

Philip L. Brower, Donald E. Butler, Carl F. Deering et al. · Tetrahedron Letters · 1992 · 100 citations

Pharmacy, Medicinal Chemistry, Pharmacology +5