Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways

Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005–2025

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TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

Jonathan Lam, Sunao Takeshita, Jane E. Barker et al. · Journal of Clinical Investigation · 2000 · 1.4K citations · Full text

Life Sciences, Cell Biology, Immunology +17

c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

Agamemnon E. Grigoriadis, Zhao‐Qi Wang, Marco Cecchini et al. · Science · 1994 · 1.3K citations

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Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

Nobuyuki Udagawa, N. Takahashi, Takuhiko Akatsu et al. · Proceedings of the National Academy of Sciences · 1990 · 1K citations

Medicine, Cell Biology, Immunology +14

Requirement for NF-κB in osteoclast and B-cell development

Guido Franzoso, Louise Carlson, Lianping Xing et al. · Genes & Development · 1997 · 994 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10