Chemical Communications · 2013 · 60 citations · 20 references
PharmacyMedicinal ChemistryPharmacologyDrug DeliveryOrganometallic ChemistryStructure-activity RelationshipsCoordination ChemistryLigand BindingLigand-receptor InteractionsProtein-ligand BindingProtein-ligand InteractionsReceptor-ligand InteractionsCellular AccumulationCellular Drug AccumulationDrug-ligand ComplexationIntermolecular Metal-ligand InteractionsIntracellular DistributionIntracellular Drug DistributionLigand ChemistryProtein-ligand Complexes
Titanium(IV) complexes with a salan or cyclopentadienyl ligand showed different biological behaviour concerning binding to biomolecules, cellular accumulation and intracellular distribution. Binding efficacy as well as trafficking on the cellular level are crucial parameters for their biological effects.
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Maolin Guo, Hongzhe Sun, Harry J McArdle et al. · Biochemistry · 2000 · 226 citations
Medicine, Oncology, Pharmacology +15
Novel benzyl substituted titanocene anti-cancer drugs
Nigel J. Sweeney, Óscar Mendoza, Helge Müller‐Bunz et al. · Journal of Organometallic Chemistry · 2005 · 126 citations