Automated Solubility Determination Using a Customized Robotic System and a Turbidity Probe

Abstract

In chemical development, broad knowledge of solubilities of all reactants, reagents, and products is important because these data are needed for cleaning operations of multipurpose equipment in pilot and production plants. A fully automated workflow on a high-throughput robotic system for determination of solid material solubility in different aqueous and organic solvents is described. Automated solid dispensing, weighing, and solvent addition are performed followed by direct measurement of turbidity with an integrated three-wavelength turbidity probe. Finally, a report is generated containing all solubility information of the solid in a clearly arranged manner. (JALA 2005;10:408–11)